Yellow Fever Vaccine
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What is Yellow fever ?
Patients with yellow fever may be viremic (have virus in their blood) for 3 to 6 days before demonstrating symptoms. Initial symptoms include fever and chills, severe headache, back pain, general muscle aches, nausea, fatigue, and weakness. This phase may be followed by a short period of symptom remission.The toxic phase develops as the fever returns, with clinical symptoms including high fever, headache, back pain, nausea, vomiting, abdominal pain, and fatigue. Hepatic coagulopathy produces hemorrhagic symptoms, including hematemesis (black vomit), epistaxis (nose bleed), gum bleeding, and petechial and purpuric hemorrhages (bruising). Deepening jaundice and proteinuria frequently occur in severe cases.In the late stages of disease, patients can develop hypotension, shock, metabolic acidosis, acute tubular necrosis, myocardial dysfunction, and cardiac arrhythmia. Confusion, seizures, and coma can also occur. When epidemics occur in unvaccinated populations, case-fatality rates range from 15% to more than 50%. Secondary bacterial infections and kidney failure are complications. Symptoms of weakness and fatigue may last several months in people who recover.Those who recover from yellow fever generally have lasting immunity against subsequent infection.
Yellow fever vaccine is a live virus vaccine which has been used for several decades. A single dose confers immunity lasting 10 years or more. If a person is at continued risk of yellow fever infection, a booster dose is needed every 10 years. Adults and children over 9 months can take this vaccine.
This vaccine is only administered at designated yellow fever vaccination centers.